The Effects of Eupatilin (StillenⓇ) on Motility of Human Lower Gastrointestinal Tracts
Seung-Bum Ryoo1, Heung-Kwon Oh1, Sung A Yu1,2, Sang Hui Moon1, Eun Kyung Choe1,3, Tae Young Oh4, and Kyu Joo Park1
1Division of Colorectal Surgery, Department of Surgery, 2Department of Physiology, Seoul National University College of Medicine, Seoul 110-744, 3Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul 135-984, 4Dong-A, Pharmaceutical Co, Seoul 130-823, Korea
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Gastrointestinal motility consists of phasic slow-wave contractions and the migrating motor complex (MMC). Eupatilin (StillenⓇ) has been widely used to treat gastritis and peptic ulcers, and various cytokines and neuropeptides are thought to be involved, which can affect gastrointestinal motility. We performed a study to identify the effects of eupatilin on lower gastrointestinal motility with electromechanical recordings of smooth muscles in the human ileum and colon. Ileum and colon samples were obtained from patients undergoing bowel resection. The tissues were immediately stored in oxygenated Krebs-Ringer's bicarbonate solution, and conventional microelectrode recordings from muscle cells and tension recordings from muscle strips and ileal or colonic segments were performed. Eupatilin was perfused into the tissue chamber, and changes in membrane potentials and contractions were measured. Hyperpolarization of resting membrane potential (RMP) was observed after administration of eupatilin. The amplitude, AUC, and frequency of tension recordings from circular and longitudinal smooth muscle strips and bowel segments of the ileum and colon were significantly decreased after admission of eupatilin. Eupatilin elicited dose-dependent decreases during segmental tension recordings. In conclusion, eupatilin (StillenⓇ) showed inhibitory effects on the human ileum and colon. We propose that this drug may be useful for treating diseases that increase bowel motility, but further studies are necessary.