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Original Article

Korean J Physiol Pharmacol 2020; 24(2): 165-171

Published online March 1, 2020 https://doi.org/10.4196/kjpp.2020.24.2.165

Copyright © The Korean Journal of Physiology & Pharmacology.

Changes in plasma lipoxin A4, resolvins and CD59 levels after ischemic and traumatic brain injuries in rats

Jun-Sub Jung1,#, A Ra Kho2,#, Song Hee Lee2,#, Bo Young Choi2,#, Shin-Hae Kang3, Jae-Young Koh4, Sang Won Suh2, and Dong-Keun Song3,*

1Institute of Natural Medicine, Departments of 2Physiology and 3Pharmacology, College of Medicine, Hallym University, Chuncheon 24252, 4Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea

Correspondence to:*Dong-Keun Song
E-mail: dksong@hallym.ac.kr

#These authors contributed equally to this work.

Received: September 9, 2019; Revised: December 20, 2019; Accepted: December 20, 2019

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ischemic and traumatic brain injuries are the major acute central nervous system disorders that need to be adequately diagnosed and treated. To find biomarkers for these acute brain injuries, plasma levels of some specialized pro-resolving mediators (SPMs, i.e., lipoxin A4 [LXA4], resolvin [Rv] E1, RvE2, RvD1 and RvD2), CD59 and interleukin (IL)-6 were measured at 0, 6, 24, 72, and 168 h after global cerebral ischemic (GCI) and traumatic brain injuries (TBI) in rats. Plasma LXA4 levels tended to increase at 24 and 72 h after GCI. Plasma RvE1, RvE2, RvD1, and RvD2 levels showed a biphasic response to GCI; a significant decrease at 6 h with a return to the levels of the sham group at 24 h, and again a decrease at 72 h. Plasma CD59 levels increased at 6 and 24 h post-GCI, and returned to basal levels at 72 h post-GCI. For TBI, plasma LXA4 levels tended to decrease, while RvE1, RvE2, RvD1, and RvD2 showed barely significant changes. Plasma IL-6 levels were significantly increased after GCI and TBI, but with different time courses. These results show that plasma LXA4, RvE1, RvE2, RvD1, RvD2, and CD59 levels display differential responses to GCI and TBI, and need to be evaluated for their usefulness as biomarkers.

Keywords: CD59, Ischemic brain injury, Lipoxin A4, Resolvins, Traumatic brain injury