pISSN 1226-4512 eISSN 2093-3827

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Original Article

Korean Journal of Physiology and Pharmacology 2019; 23(2): 131-139

Published online March 1, 2019 https://doi.org/10.4196/kjpp.2019.23.2.131

Copyright © Korean J Physiol Pharmacol.

Dual deep neural network-based classifiers to detect experimental seizures

Hyun-Jong Jang1,2,3 and Kyung-Ok Cho2,3,4,5,*

1Department of Physiology, College of Medicine, The Catholic University of Korea, 2Department of Biomedicine & Health Sciences, The Catholic University of Korea, 3Catholic Neuroscience Institute, 4Institute of Aging and Metabolic Diseases, 5Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Manually reviewing electroencephalograms (EEGs) is labor-intensive and demands automated seizure detection systems. To construct an efficient and robust event detector for experimental seizures from continuous EEG monitoring, we combined spectral analysis and deep neural networks. A deep neural network was trained to discriminate periodograms of 5-sec EEG segments from annotated convulsive seizures and the pre- and post-EEG segments. To use the entire EEG for training, a second network was trained with non-seizure EEGs that were misclassified as seizures by the first network. By sequentially applying the dual deep neural networks and simple pre- and post-processing, our autodetector identified all seizure events in 4,272 h of test EEG traces, with only 6 false positive events, corresponding to 100% sensitivity and 98% positive predictive value. Moreover, with pre-processing to reduce the computational burden, scanning and classifying 8,977 h of training and test EEG datasets took only 2.28 h with a personal computer. These results demonstrate that combining a basic feature extractor with dual deep neural networks and rule-based pre- and post-processing can detect convulsive seizures with great accuracy and low computational burden, highlighting the feasibility of our automated seizure detection algorithm.

Keywords: Deep learning, Epilepsy, Mice, Seizures, Spectral analysis