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Original Article

Korean J Physiol Pharmacol 2018; 22(1): 17-21

Published online January 1, 2018 https://doi.org/10.4196/kjpp.2018.22.1.17

Copyright © The Korean Journal of Physiology & Pharmacology.

Morroniside on anti-inflammation activities in rats following acute myocardial infarction

Bangxing Yu1, Guoxing Zhang2, Yi An2, and Wen Wang1,*

1Department of Experimental Animal Center, XuanWu Hospital of Capital Medical University, Beijing 100053, PR China, 2Department of Life Science, Beijing Institute of Technology University, Beijing 100081, PR China

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in AMI rats in the serum were detected with commercial kits. The expression of IL-6, IL-1β and TNF-α in myocardium was detected by Western blotting analysis. We observed a significant decline in the Q(q) wave amplitude in morroniside-treated rats after 72 h. Additionally, treatment of morroniside decreased the levels of LDH and cTnT in AMI rats. We also observed that morroniside reduced the expression of IL-6, IL-1β and TNF-α in myocardium. Taken together, our findings demonstrate that morroniside had effective anti-inflammatory properties in AMI rats.

Keywords: Acute myocardial infarction, Cytokine, Inflammation, Morroniside