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Fig. 3. Far-infrared rays (FIR) effectively activate mitochondrial biogenesis. Changes in (A) mitochondrial DNA copy number (mtDNA-CN) and (B) respiratory control ratio (RCR) per mtDNA-CN ratio under 25 mM and 5.5 mM glucose conditions. (C) Mitochondrial membrane potential (ΔΨm) was determined by measuring TMRE (tetramethylrhodamine, ethyl ester) fluorescence under 5.5 mM glucose conditions by confocal microscopy (scale bar = 50 μm). (D) TMRE region of interest fluorescence intensity per cell area ratio measurement using Image J. (E) Pgc-1a expression was analyzed by reverse transcription polymerase chain reaction. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control group.
Korean J Physiol Pharmacol 2021;25:167~175
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