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Fig. 3. IDH2 gene deficiency accelerated unilateral ureteral obstruction (UUO)-induced leukocytes infiltration. IDH2+/+ and IDH2−/− female mice were subjected to either sham or UUO operation. Kidneys were harvested 5 days after the operation. (A) Representative Western blots for Ly6G and GAPDH in the kidneys. (B) The graph summarizes Ly6G expression. **p < 0.01 vs. sham-operated own control group. Data are presented as mean ± SE (n = 4). ##p < 0.01 vs. UUO-operated IDH2+/+ group. $$p < 0.01 vs. sham-operated IDH2+/+ group. (C) Representative pictures of immunohistochemically stained kidneys against F4/80 (brown). (D) The graph summarizes F4/80 expression. Data are presented as mean ± SE from 2 independent experiments. **p < 0.01 vs. sham-operated own control group. ##p < 0.01 vs. UUO-operated IDH2+/+ group.
Korean J Physiol Pharmacol 2021;25:139~146 https://doi.org/10.4196/kjpp.2021.25.2.139
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